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Three Distinct Reactions of 3,4-Dihydroisoquinolines with Azlactones: Novel Synthesis of Imidazoloisoquinolin-3-ones, Benzo[1]quinolizin-4-ones, and Benzo[d]azocin-4-ones.

โœ Scribed by Rattana Worayuthakarn; Nopporn Thasana; Somsak Ruchirawat


Publisher
John Wiley and Sons
Year
2007
Weight
38 KB
Volume
38
Category
Article
ISSN
0931-7597

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Syntheses of aza and fluorine-substitute
โœ Xiaojun Han; Rita L. Civiello; Stephen E. Mercer; John E. Macor; Gene M. Dubowch ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 178 KB

A practical and expedient synthesis of the title compounds is described. They were prepared by Stille reaction of nitro halopyridines 4 or nitro fluro-halobenzenes 10, followed by Michael addition of tertbutyl 4-aminopiperidine-1-carboxylate to the resulting activated vinyl compounds 5 and 11, hydro