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Three-dimensional Structure in Solution of the Calcium Channel Blocker ω-Conotoxin

✍ Scribed by Paul K. Pallaghy; Brendan M. Duggan; Michael W. Pennington; Raymond S. Norton

Book ID
115626242
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
971 KB
Volume
234
Category
Article
ISSN
0022-2836

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✍ O.T. Jones; A.P. So 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 486 KB

We have prepared a series of biotinylated analogs of \(\omega\)-conotoxin ( \(\omega \mathrm{CgTx}\) ) as potent, selective markers for \(\mathrm{N}-\) type calcium channels. At \(\mathbf{p H} 9.5\), reaction of \(\omega \mathrm{CgTx}\) with amidocaproylbiotin succinimidyl ester gives three biotinyl