Three-dimensional molecular imaging using mass spectrometry and atomic force microscopy
β Scribed by Andreas Wucher; Juan Cheng; Leiliang Zheng; David Willingham; Nicholas Winograd
- Book ID
- 103819478
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 351 KB
- Volume
- 255
- Category
- Article
- ISSN
- 0169-4332
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Because the atomic force microscope (AFM) allows mo- ## I. INTRODUCTION lecular resolution imaging of hydrated specimens, it provides a unique The atomic force microscope (AFM) [1], also known as the window to the microscopic biological world. A high signal-to-noise scanning force microscope, can
A variety of biopolymers is imaged using noncontact atomic force microscopy. Samples are prepared by aerosol spray deposition of aqueous solutions on freshly cleaved mica followed by air drying. The distributions of contour lengths and chain or fibril thicknesses normal to the mica substrate can be