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Three-Dimensional Models of ACE and NEP Inhibitors and Their Use in the Design of Potent Dual ACE/NEP Inhibitors

✍ Scribed by Bohacek, Regine; De Lombaert, Stéphane; McMartin, Colin; Priestle, John; Grütter, Markus


Book ID
127360813
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
784 KB
Volume
118
Category
Article
ISSN
0002-7863

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## Abstract Several studies have suggested that the accumulation of bradykinin, or that of one its metabolites BK1–8, is involved in the occurrence of side effects such as AE associated with the use of various ACEi. In this work a novel approach combining HPLC‐UV on‐line with oaTOF‐MS and ICPMS was