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Three-Dimensional Maximum-Quantum Correlation HMQC NMR Spectroscopy (3D MAXY-HMQC)

✍ Scribed by Maili Liu; Xi-An Mao; Chaohui Ye; Jeremy K. Nicholson; John C. Lindon

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
164 KB
Volume
129
Category
Article
ISSN
1090-7807

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✦ Synopsis

The extension of two-dimensional maximum-quantum correla-Three-dimensional (3D) NMR experiments, such as 3D tion spectroscopy (2D MAXY NMR), which can be used to sim-NOESY-HMQC/HSQC (6-10), 3D TOCSY-HMQC/ plify complex NMR spectra, to three dimensions (3D) is described. HSQC (7-11), 3D NOESY-TOCSY ( 12), and a number A new pulse sequence for 3D MAXY-HMQC is presented and of derivatives (12-19), have been used extensively for resoexemplified using the steroid drug dexamethasone. The sensitivity nance assignment and structural determination of macromoland coherence transfer efficiency of the MAXY NMR approach ecules where the signal overlap in two-dimensional (2D) has also been assessed in relation to other HMQC-and HSQCspectra of larger proteins or nucleic acids is too extreme based 3D methods.

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