Three-dimensional fluid pressure mapping in porous media using magnetic resonance imaging with gas-filled liposomes
✍ Scribed by Robert H. Morris; Martin Bencsik; Anil K. Vangala; Yvonne Perrie
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 278 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0730-725X
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✦ Synopsis
This paper presents and demonstrates a method for using magnetic resonance imaging to measure local pressure of a fluid saturating a porous medium. The method is tested both in a static system of packed silica gel and in saturated sintered glass cylinders experiencing fluid flow. The fluid used contains 3% gas in the form of 3-mum average diameter gas filled 1,2-distearoyl-sn-glycero-3-phosphocholine (C18:0, MW: 790.16) liposomes suspended in 5% glycerol and 0.5% Methyl cellulose with water. Preliminary studies at 2.35 T demonstrate relative magnetic resonance signal changes of 20% per bar in bulk fluid for an echo time T(E)=40 ms, and 6-10% in consolidated porous media for T(E)=10 ms, over the range 0.8-1.8 bar for a spatial resolution of 0.1 mm(3) and a temporal resolution of 30 s. The stability of this solution with relation to applied pressure and methods for improving sensitivity are discussed.