Three-dimensional collagen matrices induce delayed but sustained activation of gelatinase A in human endothelial cells via MT1-MMP

MT1-MMP, but not secreted MMPs, influenc

MT1-MMP, but not secreted MMPs, influences the migration of human microvascular endothelial cells in 3-dimensional collagen gels

✍ Teruhiko Koike; Robert B. Vernon; Margaret A. Hamner; Eman Sadoun; May J. Reed 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB

Matrix metalloproteinases (MMPs) and their specific inhibitors the TIMPs play significant roles in angiogenesis. We investigated how the expression of specific MMPs and TIMPs by human microvascular endothelial cells (hmECs) was modulated by culture of the cells in 3-dimensional (3D) type I collagen