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Three-component synthesis of 4-aryl-1H-pyrimido[1,2-a]benzimidazole derivatives in ionic liquid

✍ Scribed by Changsheng Yao; Song Lei; Cuihua Wang; Tuanjie Li; Chenxia Yu; Xiangshan Wang; Shujiang Tu

Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 134 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.215

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✦ Synopsis

Abstract

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A green and simple synthesis of 4‐ayrl‐3,4‐dihydro‐1__H__‐pyrimido[1,2‐a]benzimidazole derivatives was accomplished in excellent yields via the reaction of aryl aldehyde, 1,3‐dicarbonyl compounds and 1__H__‐benzo[d]imidazol‐2‐amine in ionic liquid of [bmim^+^][BF]. This protocol has the advantages of easier work‐up, mild reaction conditions, high yields, and an environmentally benign procedure compared with the reported methods. J. Heterocyclic Chem., (2010).

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