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Three-component or four-component coupling reactions leading to δ-lactams. Facile synthesis of γ-acyl-δ-lactams from silyl enolates, α,β-unsaturated thioesters, and imines or amines and aldehydes via tandem Michael-imino aldol reactions

✍ Scribed by Shū Kobayashi; Ryo Akiyama; Mitsuhiro Moriwaki

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
230 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Various ?~acyl-&lactam derivatives were prepared on the basis of threecomponent (silyl enolates, a, fl-unsaturated thioesters, and imines) or four-component (silyl enolates, a,~-unsaturated thioesters, amines, and aldehydes) coupling reactions via Lewis acid-catalyzed tandem Michael-imino aldol reactions.

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ChemInform Abstract: Three-Component or
ChemInform Abstract: Three-Component or Four-Component Coupling Reactions Leading to δ -Lactams. Facile Synthesis of γ-Acyl-δ-lactams from Silyl Enolates, α,β-Unsaturated Thioesters, and Imines or Amines and Aldehydes via Tandem Michael-Imino Aldol Reactions.
✍ S. KOBAYASHI; R. AKIYAMA; M. MORIWAKI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

Three-Component or Four-Component Coupling Reactions Leading to δ -Lactams. Facile Synthesis of γ-Acyl-δ-lactams from Silyl Enolates, α,β-Unsaturated Thioesters, and Imines or Amines and Aldehydes via Tandem Michael-Imino Aldol Reactions. -The Michael reaction of silyl enol ethers and unsaturated t