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Three-component, one-pot synthesis of pyrimido[4,5-b]-quinoline and pyrido[2,3-d]pyrimidine derivatives

✍ Scribed by N. A. Hassan; M. I. Hegab; F. M. Abdel-Motti; S. H. A. Hebah; F. M. E. Abdel-Megeid; A. I. Hashem

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
537 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image

Reaction of 6‐amino‐2‐methylthiouracil and 6‐amino‐1,3‐dimethyluracil with equimoler amounts of cyclic ketones or cyclic 1,3‐diketones and the appropriate aromatic aldehydes yielded regioselectivity a series of polycyclic pyrimido[4,5‐b]quinoline and pyrido[2,3‐d]pyrimidine derivatives in good yields.

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