Three-compartment (3C) pharmacokinetic modeling is more accurate than two-compartment (2C) modeling of myocardial fibrosis gadolinium kinetics
✍ Scribed by James W Goldfarb; Wenguo Zhao; Jing Han
- Book ID
- 104499332
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 305 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1097-6647
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✦ Synopsis
We observed significantly different curve shapes in healed chronic myocardial infarction when compared with normal myocardium and found that gadolinium kinetics was more accurately modeled (greater R2) with a 3C model rather than a 2C model. 2C Modeling of fibrotic and normal myocardium showed both a significant difference between the transport into the tissue and extracellular volumes while 3C modeling showed only a significant difference between the extracellular volumes of fibrotic and normal myocardium as well as the functional existence of a third compartment in fibrotic and not in normal myocardium.