Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation

CD4+ T lymphocytes migrating in three-di

CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize β1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion

✍ Peter Friedl; Frank Entschladen; Christoph Conrad; Bernd Niggemann; Kurt S. Zänk 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 406 KB 👁 2 views

Cell migration may depend on integrin-mediated adhesion to and deadhesion from extracellular matrix ligands. This concept, however, has not yet been confirmed for T lymphocytes migrating in three-dimensional extracellular matrices. We investigated receptor involvement in T cell migration combining a