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Three additional loci of rifampicin dependence in Escherichia coli

✍ Scribed by Dabbs, Eric R.


Book ID
104726345
Publisher
Springer
Year
1982
Tongue
English
Weight
397 KB
Volume
187
Category
Article
ISSN
0026-8925

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The firA gene, a locus involved in the e
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The firA200 mutation of E. coli not only renders RNA synthesis thermosensitive but also eliminates the high-level resistance to rifampicin associated with certain mutations in the beta subunit of the RNA polymerase. A priori, the firA gene is likely to code for an essential component of the transcri

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✍ Lathe, R. ;Lecocq, J. P. πŸ“‚ Article πŸ“… 1977 πŸ› Springer 🌐 English βš– 673 KB

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✍ Bass, I. A. ;Danilevskaya, O. N. ;Mekhedov, S. L. ;Fedoseeva, V. B. ;Gorlenko, Z πŸ“‚ Article πŸ“… 1979 πŸ› Springer 🌐 English βš– 728 KB

We studied the rate of synthesis of beta-and beta'-subunits of DNA-dependent RNA polymerase and the rate of beta-polypeptide mRNA synthesis in rifampicin-treated bacteria. The chosen antibiotic doses did not significantly inhibit the total RNA and protein synthesis in rifampicin-sensitive bacteria.