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Thoroughly sampling sequence space: Large-scale protein design of structural ensembles

✍ Scribed by Stefan M. Larson; Jeremy L. England; John R. Desjarlais; Vijay S. Pande


Book ID
119982894
Publisher
Cold Spring Harbor Laboratory Press
Year
2009
Tongue
English
Weight
251 KB
Volume
11
Category
Article
ISSN
0961-8368

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Sequence alignment programs such as BLAST and PSI-BLAST are used routinely in pairwise, profile-based, or intermediate-sequencesearch (ISS) methods to detect remote homologies for the purposes of fold assignment and comparative modeling. Yet, the sequence alignment quality of these methods at low se