Thomas E. Hamm Jr. (ed.). Complications of viral and mycoplasmal infections in rodents to toxicology research and testing (Chemistry Institute of Toxicology Series). Hemisphere Publishing, Washingon 1986. 191 p. £49.95. Hard Cover

✍ Scribed by Richard W. Emmons

• Book ID: 102292727
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 143 KB
• Volume: 7
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550070217

✦ Synopsis

BOOK REVIEWS different fibre types in lung cancer may be small and can probably be safely overlooked. This assumption cannot be made for mesothelioma where consistent evidence has been obtained that almost all peritoneal and the great majority of pleural mesotheliomas are caused by exposure to amphibole rather than chrysotile asbestos. A further difficulty in the use of extrapolation to estimate mesothelioma risk is the absence of dose-response data on which to base the extrapolation. The authors of this report faced a difficult task but I fear their conclusions have not been sufficiently informed by much relevant, albeit recently obtained, information. Their method of risk assessment seems likely to have over-estimated the level of risk for lung cancer; for mesothelioma in the absence of adequate dose-response data the risk of ambient concentrations of amphiboles and the possible risks posed by exposure to non-asbestos fibres remain uncertain and in need of data on which informed opinion can be based.