THIS ARTICLE HAS BEEN RETRACTED Acute phase response to nitroprusside-induced controlled hypotension in patients undergoing radical prostatectomy
✍ Scribed by S. N. Piper; S. W. Suttner; C. C. Schmidt; B. Kumle; W. H. Maleck; J. Boldt
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 689 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0003-2409
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✦ Synopsis
This study evaluated the effects of sodium nitroprusside‐induced controlled hypotension on the acute phase response in patients undergoing radical prostatectomy. Thirty patients were randomly allocated to two groups, a hypotension group (mean arterial blood pressure was adjusted to 50 mmHg) and a control group (mean arterial blood pressure > 70 mmHg). C‐reactive protein increased significantly in the hypotension group from 0.13 (0.23) to 9.85 (2.84) μg.ml^−1^ and in the control group from 0.15 (0.27) to 7.38 (3.02) μg.ml^−1^. In both groups, serum amyloid A increased significantly, but levels were higher in the hypotension group [585 (125) μg.l^−1^] than in the control group [460 (187) μg.l^−1^]. Interleukin‐6 increased significantly in both groups, but was higher in the hypotension group [139 (124) pg.ml^−1^] than the control group [56 (27) pg.ml^−1^]. Elastase showed no significant changes in the control group but in the hypotension group there was a significant increase from 65 (51) to 122 (75) ng.ml^−1^. Sodium nitroprusside‐induced hypotension was associated with a more pronounced acute phase reaction.