Next-generation sequencing (NGS) is a key technology in understanding the causes and consequences of human genetic variability. In this context, the validity of NGSinferred single-nucleotide variants (SNVs) is of paramount importance. We therefore developed a statistical framework to assess the fide
Thirteenth Annual Meeting of the International Genetic Epidemiology Society : Noordwijkerhout, The Netherlands, September 11–12, 2004
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 449 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
✦ Synopsis
Collagen IX proteoglycan has been implicated in hip osteoarthritis. We studied two COL9A1 markers (509-8B2 and 509-12B1) in relation to radiographical osteoarthritis (ROA) in the Rotterdam Study, a population-based study of 7983 subjects aged 55 years or over. We used two different designs; First a sibling pair study of 83 probands with multiple joints affected with ROA, and their 222 siblings yielding 445 sibling pairs who participated in the study. Second, an association study in a series of 71
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