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Thiotipin, a novel thiopeptide with a tipA promoter inducing activity produced by Streptomyces sp. DT31

✍ Scribed by Bong-Sik Yun; Tomomi Hidaka; Kazuo Furihata; Haruo Seto

Book ID: 104203438
Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 449 KB
Volume: 50
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)85660-x

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✦ Synopsis

Abstmc&-Thiotipin was isolated from the mycelimn of Srrepromyces sp. DT31 as a tipA pron~oter inducing substance. Based on various NMB studies including IH-lH COSY, HSQC. FG-HMBC. phase-sensitive 13C-~oupled HMBC (D-HMBC) and NOE, its sb~ture was established as a thiopeptide with oxaxoles, thiazoles and several modified amino acids. Minimum induction concentration of tiotipin for ripA promoter was 80 ng/ml.

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