Thiolated polycarbophil as an adjuvant f
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Vetter, A. (author);Martien, R. (author);Bernkop-Schnürch, A. (author)
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Article
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2010
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John Wiley and Sons Inc.
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English
⚖ 281 KB
The purpose of this study was to investigate the effect of thiolated polycarbophil as an adjuvant to enhance the permeation and improve the stability of a phosphorothioate antisense oligonucleotide (PTO-ODN) on the nasal mucosa. Polycarbophil-cysteine (PCP-Cys) was synthesized by the covalent attach