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Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44

✍ Scribed by Anelli, T.

Book ID: 111751481
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 237 KB
Volume: 22
Category: Article
ISSN: 0261-4189
DOI: 10.1093/emboj/cdg491

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The lumen of the endoplasmic reticulum (ER) contains a number of soluble proteins, many of which help the maturation of newly synthesized secretory proteins. Retention of these resident proteins in the ER is dependent on a carboxy-terminal signal, which in animal cells is usually Lys-Asp-Glu-Leu (KD