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Thioctic acid modification of oligonucleotides using an H-phosphonate

✍ Scribed by Jennifer A. Dougan; Andrew. K. Reid; Duncan Graham

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 301 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.08.107

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✦ Synopsis

The H-phosphonate of a derivative of thioctic acid (TA) was synthesised and used to introduce a disulfide moiety at the 5 0 -end of oligonucleotides. This method overcomes the difficulties experienced with the phosphoramidite approach when employing a cyclic disulfide in the starting alcohol. The disulfide-modified oligonucleotides are subsequently used in metallic nanoparticle (Au and Ag) and surface functionalisation for sensitive, sequence specific analytical detection strategies.

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