Thioalkyl Derivatives of Vitamin K3 and Vitamin K3 Oxide Inhibit Growth of Hep3B and HepG2 Cells

✍ Scribed by J. Kerns; S. Naganathan; P. Dowd; F.M. Finn; B. Carr

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 324 KB
• Volume: 23
• Category: Article
• ISSN: 0045-2068
• DOI: 10.1006/bioo.1995.1008

✦ Synopsis

A new hypothesis regarding the effect of vitamin (\mathrm{K}{3}) on hepatoma cell growth is presented. In brief, exploration of cell growth activity has been identified with the action of p34 (4^{\text {dc2 }}) kinase and its associated protein tyrosine phosphatase. After exploring a series of substituted derivatives of vitamin (\mathrm{K}) and vitamin (\mathrm{K}{3}) oxide, we suggest a mechanism involving alkylation at the active-site cysteine for the inhibition of the protein tyrosine phosphatase which controls the activity of the p34 ({ }^{\text {cdc2 }}) kinase. 1995 Academic Press. Inc.