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Thiazolobenzimidazoles, a Novel Class of Enterovirus Inhibitors, Target the 2C Protein

✍ Scribed by Armando M. De Palma; Ward Heggermont; Erik De Clercq; Alba Chimirri; Johan Neyts


Book ID
113457558
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
50 KB
Volume
74
Category
Article
ISSN
0166-3542

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Compounds 6-13 were prepared starting from 1-(triphenlymethy1)-protected 1H-imidazoles 14 and 15 in several steps. Lithiation with BuLi in T H F followed by reaction with (triphcny1methoxy)acetaldehyde (16) afforded 17 and 18, respectively. 0-Methylation of 17 and 18 gave diethers 19 and 20, respect