Thiazides XI: Partitioning of chlorothiazide in red blood cells after oral administration

✍ Scribed by Vinod P. Shah; Mark A. Walker; John P. Hunt; Donald Schuirmann; Vadlamani K. Prasad; Bernard E. Cabana

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 369 KB
• Volume: 5
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510050108

✦ Synopsis

Uptake of chlorothiazide by red blood cells after oral drug administration was investigated. Chlorothiazide was administered to normal healthy volunteers as a solution or a tablet. Frequent blood samples were collected and analysed by a specific HPLC method. The results indicate that there is a significant uptake of chlorothiazide by red blood cells, resulting in a higher blood AUC compared to plasma AUC.