Thiadiazole: A new family of intercalative photonuclease with electron transfer and radical mechanisms

✍ Scribed by Yonggang Li; Yufang Xu; Xuhong Qian; Baoyuan Qu

• Book ID: 104364055
• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 168 KB
• Volume: 13
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(03)00737-6

✦ Synopsis

A new family of photonuclease, thiadiazole-naphthalimide were synthesized and evaluated. Thiadiazole group was incorporated for the first time. These compounds intercalated into DNA efficiently and damaged DNA as low as 10 mM photochemically. Mechanism experiment showed that electron transfer and radicals were involved.