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Thermosensitization by Methylglyoxal Bis(guanylhydrazone) in Chinese Hamster Cells

✍ Scribed by Junji Miyakoshi and Shin-Ichiro Heki

Book ID
124661974
Publisher
Bioone
Year
1983
Tongue
English
Weight
307 KB
Volume
96
Category
Article
ISSN
0033-7587

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✍ Mary Anne Heaton; Wayne F. Flintoff πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 709 KB

Chinese hamster ovary cells spontaneously resistant to the cytotoxic action of methylglyoxal-bis(guany1hydrazonc) have been isolated in a multistep selection scheme. A low-level resistant isolate has been shown to be defective in the ability to accumulate the drug intracellularly. This was reflected