Thermosensitive nanoparticles prepared from poly(N-isopropylacrylamide-acrylamide-vinilpyrrolidone) and its blend with poly(lactide-co-glycolide) for efficient drug delivery system
✍ Scribed by Roya Salehi; Soodabeh Davaran; Mohammad R. Rashidi; Ali Akbar Entezami
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 298 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0021-8995
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✦ Synopsis
Abstract
Temperature‐responsive polymers have become increasingly attractive as carrier for the injectable drug delivery systems. In the present work, we have studied the preparation of poly(N‐isopropylacrylamide‐acrylamide‐vinilpyrrolidone) (NIPAAm‐AAm‐VP terpolymer) nanoparticulated terpolymer and its blend with poly(lactide‐co‐glycolide, PLGA; molar ratio of lactide/glycolid 1/3). Thermosensitive terpolymer, poly(NIPAAm‐AAm‐VP) was prepared by free‐radical polymerization in aqueous solution. The nanoparticles of poly(NIPAAm‐AAm‐VP) and its blend with PLGA containing naltrexone were prepared using the evaporation and w/o emulsion‐solvent evaporation methods, respectively. Nanoparticles prepared from terpolymer‐PLGA blend at low polymer concentration (5%) shows larger particle size (>300 nm) and higher drug content%. Various types of nanoparticles showed a burst release of less than 10% after 24 h. The results suggest that by regulating different variables, desired release profiles of naltrexone can be achieved using a blend of PLGA‐poly(NIPAAm‐AAm‐VP) nanoparticulate system. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009