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Thermosensitive Micelles Self-Assembled by Novel N-Isopropylacrylamide Oligomer Grafted Polyphosphazene

✍ Scribed by Jian Xiang Zhang; Li Yan Qiu; Kang Jie Zhu; Yi Jin

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
135 KB
Volume
25
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

Summary: A novel thermosensitive amphiphilic copolymer of PNIPAm grafted polyphosphazene (PNIPAm‐g‐PPP) has been synthesized through a co‐substitution reaction of poly(dichlorophosphazene) with amino terminated NIPAm oligomer and glycine ethyl ester (GlyEt). The polymer obtained had a molar ratio of 1:5.25 PNIPAm to GlyEt and had a lower critical solution temperature (LCST) near 30 °C. The formation of polymeric micelles was confirmed by fluorescence, dynamic light scattering and transmission electron microscopy measurements.

The structure and formation of thermosensitive micelles of poly(N‐isopropylacrylamide) grafted polyphosphazenes synthesized here.

imageThe structure and formation of thermosensitive micelles of poly(N‐isopropylacrylamide) grafted polyphosphazenes synthesized here.

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