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Thermosensitive and Dissolution Properties in Nanocomposite Polymer Hydrogels

✍ Scribed by Chia-Jung Wu; Gudrun Schmidt

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
449 KB
Volume
30
Category
Article
ISSN
1022-1336

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✦ Synopsis

Abstract

We investigate the phase transition behavior and dissolution resistant properties of thermo‐sensitive nanocomposite hydrogels made from PEO‐PPO‐PEO triblock copolymer (Pluronic F127) and Laponite silicate nanoparticles. The rapid dissolution properties of F127 copolymer hydrogels usually limit their use as sustained release drug carriers. We overcome this limitation by synergistic combination of nanoparticle gelation characteristics with polymer thermo‐sensitivity. We present a proof of concept that the temperature‐dependent phase transitions can be shifted as a function of hydrogel composition and that the dissolution of the polymer hydrogels as well as the release of a model drug, albumin, can be significantly slowed down by addition of nanoparticles. The dissolution resistant properties generated will prove useful in the future formulation, processing and application of our polymer hydrogels for sustained release drug delivery carriers.

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