Thermoresponsive, Hydrolytically Degradable Polymer Micelles Intended for Radionuclide Delivery
✍ Scribed by Martin Hruby; Cestmir Konak; Jan Kucka; Miroslav Vetrik; Sergey K. Filippov; David Vetvicka; Hana Mackova; Goran Karlsson; Katarina Edwards; Blanka Rihova; Karel Ulbrich
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 384 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
Novel polymer micelles, prepared by self‐assembling thermoresponsive poly(N‐isopropylacrylamide)__‐graft‐__poly[N‐(2‐hydroxypropyl)methacrylamide] copolymers with hydrolytically degradable N‐glycosylamine groups between the polymer blocks are proposed for delivery of diagnostic and therapeutic radionuclides into solid tumors. The micelles are formed by fast heating of an aqueous solution of the copolymer to 37 °C. They have a hydrodynamic diameter of 128 nm (measured using dynamic light scattering) and slowly degrade during incubation in aqueous buffer at pH = 7.4. Labeling with both ^131^I and ^90^Y proceeds with high yields (>85%). The unlabeled polymers are not cytotoxic for any of the tested murine and human cell lines.
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