Pathophysiology of motor fluctuations in
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Katherine Widnell
📂
Article
📅
2005
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John Wiley and Sons
🌐
English
⚖ 123 KB
Loss of dopamine neurons in Parkinson's disease (PD) initiates a complex stream of effects that results in the development of tremor, bradykinesia, and rigidity. While levodopa remains the most effective drug for the symptomatic treatment of PD, its chronic administration is associated with the deve