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Thermophilic bacterial DNA polymerases with reverse-transcriptase activity

โœ Scribed by Harini Shandilya; Kate Griffiths; ElizabethK. Flynn; Mekbib Astatke; Po-Jen Shih; JunE. Lee; GaryF. Gerard; MorelandD. Gibbs; PeterL. Bergquist

Publisher
Springer
Year
2004
Tongue
English
Weight
528 KB
Volume
8
Category
Article
ISSN
1431-0651

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Differential inhibition of DNA polymerase and RNase H activities of the reverse transcriptase by phosphonoformate
โœ Miriam Margalith; Haya Falk; Amos Panet ๐Ÿ“‚ Article ๐Ÿ“… 1982 ๐Ÿ› Springer ๐ŸŒ English โš– 439 KB

Three potential inhibitors of reverse transcriptase activities, phosphonoformate (PF), phosphonoacetate (PAA), and ethyl-diethyl phosphonoformate (Et-PF), were compared in this study. Only PF was found to inhibit the DNA polymerase activity of the purified reverse transcriptase of Moloney murine leu