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Thermodynamics versus kinetics in hetero-Michael cyclizations: a highly stereoselective approach to access both epimers of a C-d-mannopyranoside

✍ Scribed by Vincent Aucagne; Arnaud Tatibouët; Patrick Rollin


Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
189 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis


O O O 2 4, > 95% a 3, < 5% THF, RT 18 h tBuOK 0.25 equiv. Scheme 3. Hetero-Michael cyclization under thermodynamic control: production of a b-C-mannopyranoside. a : 95% isolated yield.