Though there is an advantage in using the higher solubility amorphous state in cases where low solubility limits absorption, physical instability poses a significant barrier limiting its use in solid oral dosage forms. Unlike chemical instability, where useful accelerated stability testing protocols
Thermodynamics, Molecular Mobility and Crystallization Kinetics of Amorphous Griseofulvin
β Scribed by Zhou, Deliang; Zhang, Geoff G. Z.; Law, Devalina; Grant, David J. W.; Schmitt, Eric A.
- Book ID
- 118152807
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 266 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1543-8384
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π SIMILAR VOLUMES
that the crystal growth process of the SSR drug seems to be controlled by the intramolecular motions involving the b a -relaxation mode and not by the molecular motions responsible for the a a -relaxation mode in the range of temperatures >T g . Subsequent studies will focus on the crystallization p
This work relates the thermodynamic quantities (Gc, Hc, and Sc) and the molecular mobility values (1/tau) of five structurally diverse amorphous compounds to their crystallization behavior. The model compounds included: ritonavir, ABT-229, fenofibrate, sucrose, and acetaminophen. Modulated temperatu