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Thermodynamics and molecular dynamics simulations of calcium binding to the regulatory site of human cardiac troponin C: evidence for communication with the structural calcium binding sites

✍ Scribed by Rachel A. Skowronsky, Mechthild Schroeter…


Book ID
120921601
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
532 KB
Volume
18
Category
Article
ISSN
1432-1327

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The Ca(2+)/Mg(2+)-dependent interactions between TnC and TnI play a critical role in regulating the 'on' and 'off' states of muscle contraction as well as maintaining the structural integrity of the troponin complex in the off state. In the present study, we have investigated the binding interaction