✦ LIBER ✦

Thermodynamic stability and crystal structures for polymorphs and solvates of formoterol fumarate

✍ Scribed by K. Jarring; T. Larsson; B. Stensland; I. Ymén

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 403 KB
Volume: 95
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.20571

No coin nor oath required. For personal study only.

✦ Synopsis

Polymorph screening of formoterol fumarate was performed in 12 solvents, followed by evaluations of thermodynamic stability. Three anhydrates, a dihydrate, a diethanolate, a diisopropanolate, and a dibensylalcoholate were found. The crystal structure of three solvated modifications and of the most stable anhydrate was investigated. This indicated that solvation is needed to get a stable and well packed crystal structure. Thermodynamic testing suggests that five crystal modifications are thermodynamically stable, at different conditions, since they are all reversibly related to each other.

📜 SIMILAR VOLUMES

Zwitterionic nature of tenoxicam: Crysta

Zwitterionic nature of tenoxicam: Crystal structures and thermal analyses of a polymorph of tenoxicam and a 1:1 tenoxicam:Acetonitrile solvate

✍ Mino R. Caira; Luigi R. Nassimbeni; Meredith Timme 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 482 KB

The products of recrystallization of tenoxicam (4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3- carboxamide 1,1-dioxide) from ethanol and acetonitrile were investigated by thermogravimetric analysis, differential scanning calorimetry, and X-ray diffraction. Recrystallization from e

ChemInform Abstract: Synthesis and Cryst

ChemInform Abstract: Synthesis and Crystal Structure Determination of a New Pressure-Induced Iridium Ditelluride Phase, m-IrTe2, and Comparison of the Crystal Structures and Relative Stabilities of Various IrTe2 Polymorphs.

✍ S. Jobic; R. Brec; C. Chateau; J. Haines; J.-M. Leger; H.-J. Koo; M.-H. Whangbo 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

On the irrelevance of electrostatics for

On the irrelevance of electrostatics for the crystal structures and polymorphism of long even n-alkanes

✍ Jacco Van de Streek; Paul Verwer; Piet Bennema; Elias Vlieg 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB

## Abstract It is known that the experimental triclinic crystal structures of even __n__‐alkanes are not well reproduced upon energy minimization with current force fields. The inclusion of electrostatics does not solve this, and, moreover, some charge schemes show unphysical features such as posit

ChemInform Abstract: X-Ray Crystal Struc

ChemInform Abstract: X-Ray Crystal Structures of [XeF][MF6] (M: As, Sb, Bi), [XeF][M2F11] (M: Sb, Bi) and Estimated Thermochemical Data and Predicted Stabilities for Noble-Gas Fluorocation Salts Using Volume-Based Thermodynamics.

✍ Hugh St. A. Elliott; John F. Lehmann; Helene P. A. Mercier; H. Donald Brooke Jen 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 20 KB

Solvent-shared radical ion pairs [pyrene

Solvent-shared radical ion pairs [pyrene·⊖Na⊕(C2H5)2]∞: ESR evidence for two different aggregates in solution, room temperature crystallization, and structural proof of another polymorphic modification

✍ Christian Näther; Hans Bock; Rodney F. C. Claridge 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 German ⚖ 466 KB 👁 1 views

ChemInform Abstract: Preparation, X-Ray

ChemInform Abstract: Preparation, X-Ray Crystal Structure Determination, Lattice Potential Energy, and Energetics of Formation of the Salt S4(AsF6)2×AsF3 Containing the Lattice-Stabilized Tetrasulfur [2+] Cation. Implications for the Understanding of the Stability of X42+ and X2+ (X: S, Se, and Te) Crystalline Salts.

✍ T. Stanley Cameron; Isabelle Dionne; H. Donald Brooke Jenkins; Simon Parsons; Ja 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 2 views