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Thermodynamic parameters of the reversible isomerization of aspartic residues via a succinimide derivative

✍ Scribed by Sante Capasso


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
435 KB
Volume
286
Category
Article
ISSN
0040-6031

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The aspartate residue (Asp 32) located in the complementarity-determining region (CDR) of a recombinant humanized monoclonal antibody (MAb I) is highly susceptible to the isomerization reaction. The modification of Asp 32 residue due to the isomerization reaction results in a significant reduction i