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Thermodynamic origin of the solubility profile of drugs showing one or two maxima against the polarity of aqueous and nonaqueous mixtures: Niflumic acid and caffeine

✍ Scribed by Bustamante, P. (author);Navarro, J. (author);Romero, S. (author);Escalera, B. (author)


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
132 KB
Volume
91
Category
Article
ISSN
0022-3549

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Thermodynamic origin of the solubility p
✍ Bustamante, P. (author);Navarro, J. (author);Romero, S. (author);Escalera, B. (a 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

The purpose of this work was to investigate the origin of the different solubility pro®les of drugs against the polarity of solvent mixtures with a common cosolvent. Ni¯umic acid and caffeine where chosen as model drugs. The solubilities were measured at ®ve or six temperatures in aqueous (ethanol±w