Thermodynamic and Kinetic Effects of Morpholino Modification on Pyrimidine Motif Triplex Nucleic Acid Formation under Physiological Condition

2′-O,4′-C-Aminomethylene-Bridged Nucleic

2′-O,4′-C-Aminomethylene-Bridged Nucleic Acid Modification with Enhancement of Nuclease Resistance Promotes Pyrimidine Motif Triplex Nucleic Acid Formation at Physiological pH

✍ Prof. Hidetaka Torigoe; Dr. S. M. Abdur Rahman; Hiroko Takuma; Norihiro Sato; Pr 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 381 KB 👁 1 views

## Abstract Due to the instability of pyrimidine motif triplex DNA at physiological pH, triplex stabilization at physiological pH is crucial in improving its potential in various triplex‐formation‐based strategies in vivo, such as gene expression regulation, genomic DNA mapping, and gene‐targeted m