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Thermodynamic and Kinetic Characterization of Antisense Oligodeoxynucleotide Binding to a Structured mRNA

โœ Scribed by Walton, S. Patrick; Stephanopoulos, Gregory N.; Yarmush, Martin L.; Roth, Charles M.

Book ID
118514882
Publisher
Biophysical Society
Year
2002
Tongue
English
Weight
330 KB
Volume
82
Category
Article
ISSN
0006-3495

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โœ S. Patrick Walton; Gregory N. Stephanopoulos; Martin L. Yarmush; Charles M. Roth ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 165 KB ๐Ÿ‘ 1 views

Antisense oligonucleotides, which act through the pairing of complementary bases to an RNA target sequence, are showing great promise in research and clinical applications. However, the selection of effective antisense oligonucleotides has proven more difficult than initially presumed. We developed