## Abstract A tandem mass spectrometric study of protonated isomeric hydroxypyridine __N__‐oxides was carried out with a hybrid quadrupole/time‐of‐flight mass spectrometer coupled with different atmospheric pressure ionization sources. The behavior observed in the collision‐induced dissociation (CI
✦ LIBER ✦
Thermally Induced N-to-O Rearrangement of tert - N -Oxides in Atmospheric Pressure Chemical Ionization and Atmospheric Pressure Photoionization Mass Spectrometry: Differentiation of N-Oxidation from Hydroxylation and Potential Determination of N-Oxidation Site
✍ Scribed by Ma, Shuguang; Chowdhury, Swapan K.; Alton, Kevin B.
- Book ID
- 118737750
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 182 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0003-2700
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In the pharmaceutical industry, a higher attrition rate during the drug discovery process means a lower drug failure rate in the later stages. This translates into shorter drug development time and reduced cost for bringing a drug to market. Over the past few years, analytical strategies based on li