✦ LIBER ✦

Thermal resistance of human malignant melanoma modulated by prostaglandin E2

✍ Scribed by David H. Kern; David N. Krag; Gordon L. Kauffman Jr.; Donald L. Morton; F. Kristian Storm

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 513 KB
Volume: 37
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930370117

No coin nor oath required. For personal study only.

✦ Synopsis

The inhibition of DNA synthesis in a human malignant melanoma cell line as measured by tritiated thymidine (3H-TdR) incorporation was both time- and temperature dependent. Two components of cell damage were identified: a cytostatic, temporary component from which cells recovered within 2-6 days, and a cytotoxic, permanent component from which no recovery was observed. Thermotolerance was induced in M14 cells by sublethal heat treatment at 41 degrees C for 1 hr. However, induction of thermotolerance was blocked by indomethacin, a prostaglandin synthetase inhibitor. Exogenous PGE2 at concentrations up to 10 micrograms/ml also protected cells from heat damage. These data suggest that prostaglandin synthesis increases during heat stress and may play a role in protecting cells from thermal damage.

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