Thermal, phase transition and spectral studies in erythromycin pseudopolymorphs: dihydrate and acetone solvate

✍ Scribed by Zhanzhong Wang; Jingkang Wang; Leping Dang

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 191 KB
• Volume: 41
• Category: Article
• ISSN: 0232-1300
• DOI: 10.1002/crat.200610753

✦ Synopsis

Abstract

The thermal, phase transition and spectral studies of erythromycin A dihydrate and acetone solvate were performed by Differential Scanning calorimetry (DSC), Thermo Gravimetry (TG‐DTA), X‐Ray Powder Diffraction (XRPD) and Fourier Transform Infra‐Red (FTIR) spectrum. The non‐thermal kinetic analysis of erythromycin A dihydrate was carried out by DSC at different heating rates in dynamic nitrogen atmosphere. The result showed that heating rate has substantial influence on the thermal behavior of erythromycin dihydrate. The Arrhenius parameters were estimated according to the Kissinger method. Corresponding to dehydration of dihydrate, melting of dehydrated dihydrate, phase transition from dehydrated dihydrate to anhydrate, and melting of anhydrate, the calculated activation energy were 39.60, 269.85, 261.23, and 582.16 kJmol^–1^, the pre‐exponential factors were 3.46 × 10^3^, 8.06 × 10^32^, 9.23 × 10^30^, and 7.29 × 10^63^ s^–1^, respectively. Ozawa method was used to compare activation energy values calculated by Kissinger method. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)