Thermal denaturation of wild type and mutant recombinant acetylcholinesterase from amphioxus: effects of the temperature of in vitro expression and of reversible inhibitors

Rapid binding of a cationic active site

Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge

✍ Sylvia Tara; Adrian H. Elcock; Paul D. Kirchhoff; James M. Briggs; Zoran Radic; 📂 Article 📅 1998 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 133 KB 👁 2 views

It is known that anionic surface residues play a role in the long-range electrostatic attraction between acetylcholinesterase and cationic ligands. In our current investigation, we show that anionic residues also play an important role in the behavior of the ligand within the active site gorge of ac