Thermal behavior and elastic properties of phospholipid bilayers under the effect of a synthetic flavonoid derivative, LEW-10

✍ Scribed by B. Azize; A. Cao; E. Hantz-Brachet; G. Perret; G. Lewin; E. Taillandier

• Book ID: 103042243
• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 622 KB
• Volume: 63
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(92)90033-l

✦ Synopsis

We have investigated the effect on phospholipidic bilayers of LEW-10, a synthetic flavonoid, derivative of diosmin. Two optical techniques, Quasi-elastic Light Scattering (QLS) and Fourier Transform Infrared Spectroscopy (FT-IR) were used. The results show that in the presence of LEW-10, the phase transition of the bilayers is lowered and that the elastic modulus is decreased. The FT-IR results indicate interactions in the aqueous interface regions of the bilayers. We also discuss LEW-10 comparatively with another derivative, LEW-7/SI, whose effect has been previously studied.