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Therapy-related acute myeloid leukaemia with mutated NPM1: treatment induced or de novo in origin?

✍ Scribed by Falini, B


Book ID
109886783
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
61 KB
Volume
22
Category
Article
ISSN
0887-6924

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Mutations of NPM1 gene in de novo acute
✍ Firoz Ahmad; Swarna Mandava; Bibhu Ranjan Das πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 371 KB

## Abstract Mutations in the nucleophosmin (__NPM1__) gene have been recently described to occur in about one‐third of acute myeloid leukaemias (AMLs) and represent the most frequent genetic alteration currently known in this subset, specially in those with normal karyotype. This study explored the