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Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody

✍ Scribed by Yoshizaki, Kazuyuki ;Nishimoto, Norihiro ;Mihara, Masahiro ;Kishimoto, Tadamitsu

Publisher: Springer
Year: 1998
Tongue: English
Weight: 774 KB
Volume: 20
Category: Article
ISSN: 0344-4325
DOI: 10.1007/bf00832010

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## Abstract ## Objective Interleukin‐6 (IL‐6) is a pleiotropic cytokine that regulates the immune response, inflammation, and hematopoiesis. Overproduction of IL‐6 plays pathologic roles in rheumatoid arthritis (RA), and the blockade of IL‐6 may be therapeutically effective for the disease. This s

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