Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
โ Scribed by Ram, Zvi; Culver, Kenneth W.; Oshiro, Eric M.; Viola, John J.; DeVroom, Hetty L.; Otto, Edward; Long, Zhifeng; Chiang, Yawen; McGarrity, Gerard J.; Muul, Linda M.
- Book ID
- 109932742
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 967 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1078-8956
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An implant heating system using a ferromagnetic implant with low Curie temperature has been developed for treating human brain tumors. Safe and repeated hyperthermia was possible over periods averaging ten weeks in 23 out of 25 patients with malignant brain tumors without development of major side e
## Abstract Abstract: We explored the possibility of entrapping retroviral vector producing cells (VPC) within porous 3D matrix to induce a local and sustained release of viral particles to the malignant milieu. PA317/STK, which constantly shed reroviral vectors, was used to transduce cancer cells