Therapy of chronic hepatitis B virus infection: inhibition of the viral polymerase and other antiviral strategies
β Scribed by Fabien Zoulim
- Book ID
- 114145254
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 709 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0166-3542
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## Abstract Primary duck hepatocyte (PDH) cultures, congenitally infected with the duck hepatitis B virus (DHBV), were grown on feeder cell layers of irradiated human embryonic lung fibroblasts and then exposed to a number of compounds with recognized or potential antiviral activity. These compound
A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combinati
## Abstract Primary duck hepatocyte (PDH) cultures were established from ducklings congenitally infected with the duck hepatitis B virus (DHBV), plated onto feeder cell layers of irradiated human embryonic lung fibroblasts, and observed for 2 to 3 weeks. This system permitted the survival of the PD