𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Therapy of acute hepatitis C with interferon: How good is it really?

✍ Scribed by Jorge J. Gumucio; Jorge Rakela; David D. Douglas

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
265 KB
Volume
16
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

To test whether interferon can prevent acute non-A, non-B hepatitis from becoming chronic, a prospective controlled trial was conducted in 26 patients; 11 were treated for an average of 30 days with a mean of 52 megaunits of interferon and 14 acted as controls. 4 patients in the treatment group who continued to have raised serum aminotransferase concentrations after a year's follow-up were given a second course of interferon. Follow-up at 3 years has revealed that all but 1 of those treated showed normal serum aminotransferaae, whereas only 3 controls showed such change (p < 0.02). Serum hepatitis C virus RNA became undetectable in 10 of 11 treated and in only 1 of 12 control patients, which suggests that interferon prevents the progression of acute non-A, non-B hepatitis to chronicity by eradicating HCV.

📜 SIMILAR VOLUMES

A mutation in the interferon sensitivity
A mutation in the interferon sensitivity-determining region is associated with responsiveness to interferon-ribavirin combination therapy in chronic hepatitis patients infected with a Japan-specific subtype of hepatitis C virus genotype 1b
✍ Mutsumi Murayama; Yoshiaki Katano; Isao Nakano; Masatoshi Ishigami; Kazuhiko Hay 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 178 KB 👁 2 views

## Abstract The interferon sensitivity‐determining region (ISDR) is useful as a predictive marker of the response to interferon (IFN) therapy for chronic hepatitis patients with a Japan‐specific subtype (J‐type) of hepatitis C virus (HCV) genotype 1b. This marker is not useful for predicting respon

Loss of serum HCV RNA at week 4 of inter
Loss of serum HCV RNA at week 4 of interferon-α therapy is associated with more favorable long-term response in patients with chronic hepatitis C
✍ Etsuro Orito; Masashi Mizokami; Kaoru Suzuki; Ken-Ichi Ohba; Tomoyoshi Ohno; Mas 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 554 KB

## Abstract To determine the virological factors associated with a favorable long‐term response to interferon‐α (IFN) therapy in chronic hepatitis C virus (HCV) infection, 61 Japanese patients with chronic HCV infection were treated with IFN for 24 weeks (780 million units in total) and followed fo

Virological response is associated with
Virological response is associated with decline in hemoglobin concentration during pegylated interferon and ribavirin therapy in hepatitis C virus genotype 1
✍ William Sievert; Gregory J. Dore; Geoffrey W. McCaughan; Motoko Yoshihara; Darre 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 336 KB 👁 1 views

Anemia may increase the likelihood of achieving a sustained virological response (SVR) during pegylated interferon and ribavirin treatment of hepatitis C virus (HCV) infection. To determine whether hemoglobin decline is associated with SVR, we retrospectively evaluated the CHARIOT study of 871 treat